Abstract
The structure of mouse skin collagen fibrils treated with 500 rad gamma irradiation was studied by electron microscopy. Examination of specimens after 1, 4 and 8 weeks of treatment revealed collagen fibrils consistently larger in diameter than those from normal specimens with the majority of irradiated fibrils measuring 110–138 nm, as opposed to 62–84 nm in the control. No marked differences in cross-linking were detected between irradiated and control reconstituted type I or type III collagen, either by polyacrylamide gel electrophoresis or by thermal stability measurements.
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