Abstract
Few studies have assessed the application and side effects of potassium iodide (KI) iontophoresis. Using a double-blinded randomized controlled trial with a 1:1 parallel-group, we investigated the effect of galvanization and the KI iontophoresis in the throat and larynx on three thyroid parameters. A total of 50 healthy volunteers with normal TSH, FT3, and FT4 levels and lacking focal changes in the thyroid ultrasonography were subjected to 10 electrotherapy treatments. The TSH, FT3, and FT4 levels were determined prior to the 10 electrotherapeutic treatments (T1), 2-weeks after treatment (T2) and 6-months after treatment (T3). At T2 and T3, both groups had normal levels of TSH, FT3, and FT4. Regarding the change of TSH, FT3, and FT4 levels between T1 vs. T2 and T1 vs. T3, no significant differences between the galvanization and iontophoresis groups were found. However, both groups had lower levels of all three hormones at T3. Together, these data indicate that KI iontophoresis does not affect thyroid hormone levels in the short- nor long-term. Additional follow-up studies with larger groups are required to better confirm the safety of galvanization and iontophoresis procedures in the pharynx and larynx.Trial registration ClinicalTrials.gov (NCT04013308; URL: www.clinicaltrials.gov). Day of first registration 09/07/2019.
Highlights
Few studies have assessed the application and side effects of potassium iodide (KI) iontophoresis
This study aimed to assess the impact of galvanization and KI iontophoresis procedures performed on the pharynx and larynx as well as the level of thyroid-stimulating hormone (TSH), FT3 and FT4 hormones
There were no significant differences between groups G and I in TSH level at T1 and T2
Summary
Few studies have assessed the application and side effects of potassium iodide (KI) iontophoresis. Using a double-blinded randomized controlled trial with a 1:1 parallel-group, we investigated the effect of galvanization and the KI iontophoresis in the throat and larynx on three thyroid parameters. Regarding the change of TSH, FT3, and FT4 levels between T1 vs T2 and T1 vs T3, no significant differences between the galvanization and iontophoresis groups were found. Both groups had lower levels of all three hormones at T3. Medical reference books enumerate various applications for the appropriate use of physiotherapeutic procedures for throat and larynx conditions[11,12,13,14] These recommendations are not appropriately grounded in published scientific data. Thyroid parameters TSH [μIU/mL] Before electrotherapy After electrotherapy Therapy effect FT3 [pg/mL] Before electrotherapy After electrotherapy Therapy effect FT4 [ng/dL] Before electrotherapy After electrotherapy Therapy effect
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