Abstract

SummaryConcurrent measurements of uric acid levels in maternal serum, fetal serum and amniotic fluid were made in 52 patients. The patients with pre‐eclampsia who were not on frusemide had higher uric acid levels in all fluids studied than did the untreated controls and frusemide increased the uric acid levels further in both types of patient. The potentially harmful effect on the fetus of high uric acid levels induced by frusemide should be considered. Raised levels of uric acid in amniotic fluid may invalidate the use of this measurement as an index of fetal maturity in patients who have pre‐eclampsia or who are on diuretics.

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