Abstract
Thirty male rats were used to study the effect of free oxygen radicals on fracture healing. The rats were divided into two groups and the right forelimbs of the rats were broken by light manual compression. One hour before the fracture the following treatments were given to groups of 15 animals; saline 5 ml/kg i.p. (control group) or zyomosan 100 mg/kg i.p. to induce free oxygen radicals through stimulation of NADPH oxidase in polymorphonuclear leucocytes. Treatment were stopped on the fifth post-fracture day. All rats were sacrificed with high dose ether on day 22, and histological sections of the radius and ulna were examined without knowledge of the treatment regiment. The administration of zymosan impaired the fracture healing and therefore free oxygen radicals appear to play an important role on fracture healing.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
