Abstract
BackgroundFluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. The pharmacokinetics of orally administered drugs may be influenced by feeding. This study investigated the influence of concurrent feeding on fluralaner pharmacokinetics.MethodsTwelve fasted or fed beagles received a single oral administration of 25 mg fluralaner/kg body weight in a chewable tablet. Plasma samples were collected at multiple post-treatment time points for fluralaner concentration analysis. Clinical observations were performed on all dogs at regular intervals throughout the study.ResultsFluralaner was readily absorbed in fasted and fed dogs administered at a dose of 25 mg/kg BW with a similar mean tmax for both groups. In fed dogs, AUC and Cmax were increased compared to fasted dogs by a factor of 2.5 and 2.1 respectively. The difference in AUC and Cmax between the fed and fasted groups was statistically significant. No adverse events were observed following oral fluralaner administration to fasted and fed dogs.ConclusionsFluralaner is absorbed to a considerable extent in fasted and fed dogs. Administration of fluralaner chewable tablets with food significantly increases bioavailability.
Highlights
Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose
The similarity between fed and fasted groups in the time to reach maximum plasma concentrations indicates that fluralaner absorption, and thereby onset of the parasiticide effect, is not delayed through feeding
Fluralaner is formulated as an oral chewable tablet and some dog owners may choose to facilitate administration by dosing at or around the time of feeding
Summary
Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. The pharmacokinetics of orally administered drugs may be influenced by feeding. This study investigated the influence of concurrent feeding on fluralaner pharmacokinetics. Fluralaner is a novel systemically administered insecticidal and acaricidal compound that provides long-acting efficacy after oral administration to dogs. A field study has shown that a single fluralaner dose administered orally to dogs provides at least twelve weeks of flea- and tick-control [1]. Feeding affects gastrointestinal physiology and may influence the pharmacokinetics of a concurrently administered drug through reduced, delayed, increased, or accelerated absorption; in addition, there are drugs with no food interaction [2,3,4]. Administration of fluralaner tablets at or around the time of feeding may
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