Abstract
Folic acid has less effect than 5-formyltetrahydofolic acid (folinic acid) in the alleviation of folate deficiency in cultured HEp 2 cells as measured by the deoxyuridine suppression test. Folic acid inhibits the metabolism of 5-formyltetra-hydrofolic acid in vitro, is contraindicated in some cases of clinical folate deficiency and may be inappropriate in others.
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