The Effect of Fish Oil-Based Lipid Emulsion and Soybean Oil-Based Lipid Emulsion on Cholestasis Associated with Long-Term Parenteral Nutrition in Premature Infants.

Leilei Wang,Jiejin Gao,Jing Zhang,Yan Qian,Ya Ling

doi:10.1155/2016/4139164

Abstract

Purpose. To retrospectively study the effect of fish oil-based lipid emulsion and soybean oil-based lipid emulsion on cholestasis associated with long-term parenteral nutrition in premature infants. Methods. Soybean oil-based lipid emulsion and fish oil-based lipid emulsion had been applied in our neonatology department clinically between 2010 and 2014. There were 61 qualified premature infants included in this study and divided into two groups. Soybean oil group was made up of 32 premature infants, while fish oil group was made up of 29 premature infants. Analysis was made on the gender, feeding intolerance, infection history, birth weight, gestational age, duration of parenteral nutrition, total dosage of amino acid, age at which feeding began, usage of lipid emulsions, and incidence of cholestasis between the two groups. Results. There were no statistical differences in terms of gender, feeding intolerance, infection history, birth weight, gestational age, duration of parenteral nutrition, total dosage of amino acid, and age at which feeding began. Besides, total incidence of cholestasis was 21.3%, and the days of life of occurrence of cholestasis were 53 ± 5.0 days. Incidence of cholestasis had no statistical difference in the two groups. Conclusion. This study did not find the different role of fish oil-based lipid emulsions and soybean oil-based lipid emulsions in cholestasis associated with long-term parenteral nutrition in premature infants.

Highlights

Parenteral nutrition related cholestasis (PNAC) is the most serious complication of the long-term parenteral nutrition (PN)
This study retrospectively investigated the role of soybean oil-based lipid emulsion and fish oil-based lipid emulsion in cholestasis associated with long-term parenteral nutrition in premature infants who were admitted to our hospital during 2010–2014
Chisquare test analysis showed that there were no differences in terms of gender, feeding intolerance, and the incidence of infection history in the two groups (Table 1). t-test analysis between the two groups showed no difference in birth weight, gestational age, age at which feeding began, or the days of life of occurrence of cholestasis (Table 1)

Summary

Introduction

Parenteral nutrition related cholestasis (PNAC) is the most serious complication of the long-term parenteral nutrition (PN). Some studies have shown that [1,2,3] omega-3 fish oil fatty acid is helpful to the recovery of cholestasis in infants. Our neonatology department has applied fish oil-based lipid emulsion and soybean oil-based lipid emulsion since 2010. This study retrospectively investigated the role of soybean oil-based lipid emulsion and fish oil-based lipid emulsion in cholestasis associated with long-term parenteral nutrition in premature infants who were admitted to our hospital during 2010–2014

Materials and Methods

Results

Discussion