Abstract
Compaction of a brittle material, phenacetin, could be improved by proper choice of the diluent and film-inducing agent. Aspirin, potassium chloride and sodium chloride were used owing to their ability to relieve stresses by plastic flow. The effect of Aerosil, Eudragit-E and magnesium stearate on the characteristics of these binary mixtures as well as their mechanism were presented. In almost all Systems the results of the repose angle and bulk density were consistent with those obtained from tensile strength measurement. Phenacetin tablets needed higher ratios of potassium chloride or sodium chloride to produce satisfactory compacts than in the case of aspirin. A linear relation was obtained by plotting log packing fraction of various potassium chloride to phenacetin binary mixtures versus log tensile strength. At a given pressure the tensile strength of phenacetin alone could be estimated.
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