Abstract
Freshly prepared human red blood cells incubated with 5 mM ferricyanide, 0.2 mM iodoacetate and 2 mM adenosine in the presence of 5 mM EGTA demonstrate comparable increases in Na + and K + permeability (ferricyanide effect). This effect is unrelated to the Ca 2+-activated K + channel (Gardos effect) since influx of Ca 2+ from outside the cell is excluded. Also this effect is different from the non-specific Na + and K + permeability change elicited by PCMBS. These differences become obvious by using various reagents. For example, A23187 and quinidine exert opposite effects in Gardos and ferricyanide experiments, where A23187 and atebrin react oppositely in the latter and in PCMBS experiments. The ferricyanide effect described here does not involve formation of nonspecific channels. The change in Na + permeability separately from K + permeability under certain circumstances suggests a more specific effect.
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