Abstract
Livers of fed and fasted rats were perfused with varying concentrations of glucose. The maximum decrease in glucose utilization occurred during the first day of starvation and was not significantly depressed by further fasting, up to 4 days. In all cases glucose utilization was increased by increasing the initial glucose concentrations in the medium from 75 to 600 mg. 100 ml. These results suggest that hepatic glucose phosphorylation during fasting and with elevated blood sugar may be mediated by the pyrophosphate may be mediated by the pyrophosphate glucose phosphotransferase reaction rather than by hexokinase or glucokinase.
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