Abstract
ABSTRACTPurpose:To investigate experimentally the effects of Tropifexor, a farnesoid X receptor agonist, on liver injury in rats with obstructive jaundice.Methods:Forty healthy Wistar albino female rats were divided randomly in selected groups. These groups were the sham group, control group, vehicle solution group, Ursodeoxycholic acid group and Tropifexor group. Experimental obstructive jaundice was created in all groups, except the sham one. In the blood samples obtained, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin and direct bilirubin levels were established and recorded. Additionally, liver malondialdehyde, myeloperoxidase and catalase enzyme activity in the tissue samples were studied. Histopathological analysis was also performed.Results:No statistical difference was found between the control group and the Tropifexor group when AST, ALT and ALP values were compared. However, it was found that the Tropifexor group had statistically significant decreases in the values of GGT, total bilirubin and direct bilirubin (p < 0.05). Additionally, Tropifexor decreased the median values of malondialdehyde and myeloperoxidase, but this difference was not statistically significant compared to the control group. Finally, the Tropifexor group was statistically significant in recurring histopathological liver damage indicators (p < 0.05).Conclusions:Tropifexor reduced liver damage due to obstructive jaundice.
Highlights
Obstructive jaundice (OJ) is the clinical condition of bile retention and jaundice which occurs due to partial or complete obstruction of intrahepatic or extrahepatic bile ducts
Since no OJ was formed in the SH group, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) and bilirubin values were lower than in the other groups
Considering the case with the ALP values, when the TPX group and the C group were compared in terms of ALT and AST, there were no statistically significant differences
Summary
Obstructive jaundice (OJ) is the clinical condition of bile retention and jaundice which occurs due to partial or complete obstruction of intrahepatic or extrahepatic bile ducts. Bile flow into the intestine is blocked in these kinds of diseases, due to the obstruction in the bile ducts, interrupting the enterohepatic cycle. In this way, bile accumulates in the liver cells and bile ducts. As a result, increased serum levels of bile acids and bilirubin can cause liver damage. This can cause other conditions such as cardiovascular problems, kidney failure, delay in wound healing, gastrointestinal bleeding, bacterial translocation, sepsis, multi-organ dysfunction, and death[1,3]
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