The effect of factor XA and thrombin on ICAM-1 expression on endothelial progenitor cells. The role of PAR-1

Abstract

Aim: Factor Xa (FXa) and thrombin are important coagulation proteases which also induce cellular pleiotropic effects that are primarily mediated through the protease activated receptors (PARs). PARs are important for thrombin- and FXa-induced cellular activation. We investigated the effect of FXa and thrombin on the membrane expression of adhesion molecule ICAM-1 on CD34+-derived late-outgrowth endothelial cells (OECs) and human umbilical vein endothelial cells (HUVECs). The role of the selective PAR-1 antagonist voraxapar was also investigated.