The effect of extract of pregnancy urine upon hypopituitarism in the male

Abstract

Summary 1.Eight male children with hypopituitarism were treated with extract of pregnancy urine (antuitrin-S). 2.Descent of the testes was accomplished in all of three cases of cryptorchism. 3.In three cases characterized by genital underdevelopment (testes descended), treatment resulted in enlargement of the testes and scrotum and the appearance of the secondary sex characteristics. 4.In two cases characterized by pituitary obesity with normal genital development, treatment resulted in no increase in size of the genitals. 5.In four of five cases receiving basal metabolism tests before and at the end of treatment, the basal metabolic rates were lowered below the lower limits of normal at the end of treatment. 6.The inconsistency of the change in blood cholesterol level following treatment does not permit definite conclusions. 7.In five cases receiving sugar tolerance determinations before and at the end of treatment, the tolerance was lowered at the end of treatment. 8.In seven of the eight cases, there was an increase in growth of stature above the normal for the age following treatment. 9.In our series of cases, antuitrin-S did not stimulate weight loss and did not alter the typical pituitary distribution of fat. Summary 1.Eight male children with hypopituitarism were treated with extract of pregnancy urine (antuitrin-S). 2.Descent of the testes was accomplished in all of three cases of cryptorchism. 3.In three cases characterized by genital underdevelopment (testes descended), treatment resulted in enlargement of the testes and scrotum and the appearance of the secondary sex characteristics. 4.In two cases characterized by pituitary obesity with normal genital development, treatment resulted in no increase in size of the genitals. 5.In four of five cases receiving basal metabolism tests before and at the end of treatment, the basal metabolic rates were lowered below the lower limits of normal at the end of treatment. 6.The inconsistency of the change in blood cholesterol level following treatment does not permit definite conclusions. 7.In five cases receiving sugar tolerance determinations before and at the end of treatment, the tolerance was lowered at the end of treatment. 8.In seven of the eight cases, there was an increase in growth of stature above the normal for the age following treatment. 9.In our series of cases, antuitrin-S did not stimulate weight loss and did not alter the typical pituitary distribution of fat.