Abstract
In contrast to normal eukaryotic tissue, which contains a single isoaccepting species of tRNA Phe, the Ehrlich ascites carcinoma contains a spectrum of tRNA Phe species varying in their relative degree of postranscriptional modification. The occurrence of multiple species involves an incomplete biosynthesis of the Y base, a complex hypermodified nucleoside located adjacent to the 3′ end of the anticodon. Following intraperitoneal innoculation of a mixture of essential amino acids and vitamins into these mice, the majority of the tumor tRNA Phe behaved like the single liver tRNA Phe species. This suggests that under these conditions the modification of Y base was completed.
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