The Effect of Exercise Type on Inflammatory Markers in Obese Survivors With Breast Cancer: Randomized Control Trial

Abstract

Background: Breast cancer is the most common cancer diagnosed in women throughout the world and the leading cause of cancer-related deaths in women Objectives: The current study aimed to investigate the effect of eight weeks of training on IL-6, TNF-α and hCRP in postmenopausal breast cancer survivors. Patients and Methods: Twenty-seven postmenopausal breast cancer survivors with mean age of 44.1 ± 4.6, mean height of 158 ± 5.9 cm and mean Body Mass Index (BMI) of 30.2 ± 3.2 kg/m2, were randomly divided to three groups; continuous, interval and the control groups. Inflammatory markers, anthropometric variables and VO2 peak were measured before and after the eight weeks. Statistical analysis of the data was carried out using the Kruskal-Wallis and Wilcoxon test at a significance level of P 0.05). The human C-Reactive Protein (hCRP) levels showed a significant reduction in the continuous group (P = 0.015), and the reductions in Tumor Necrosis Factor alpha (TNF-α) and Interleukin6 (IL-6) were also greater in this group than in the other two groups. No significant differences were observed between the two exercise groups in their inflammatory markers. Conclusions: Exercise can improve anthropometric variables, body composition and VO2 peak and reduce some inflammatory markers in breast cancer survivors.