Abstract
BackgroundMedicinal plants are used to manage pain and inflammatory disorders in traditional medicine. A scientific investigation could serve as a basis for the determination of molecular mechanisms of antinociceptive and antiinflammatory actions of herbal products. In this work, we used both artificial intelligence (AI) based models inform of adaptive neuro-fuzzy inference system and artificial neural network (ANN) as well as a linear model, namely; stepwise linear regression in modelling the performance of four different inflammatory biomarkers namely; interleukin (1L)-1β, 1L-6, tumour necrosis factor (TNF)-α and prostaglandin E2 (PGE2). This modelling was done using number of abdominal writes, the reaction time of paw licking in mice and paw oedema diameter as the input variables.ResultsFour different performance indices were employed, which are determination coefficient (DC), root mean squared error (RMSE), mean square error (MSE) and correlation co-efficient (CC). The results have shown the superiority of the AI-based models over the linear model.ConclusionsThe overall quantitative and visualized comparison of the results showed that adaptive neuro-fuzzy inference system outperformed the ANN and SWLR models in modelling the performance of the four inflammation biomarkers in both the calibration and verification phases.
Highlights
Medicinal plants are used to manage pain and inflammatory disorders in traditional medicine
Acute toxicity determination We investigated the acute toxicity study of ethanolic leaves extract of Hymenodictyon floribundun" (EEHF) in rats and mice based on the guideline specified by the Organization of Economic Co-operation and Development (OECD) 423 (OECD 2001)
Acetic acid-induced abdominal writhes result from the stimulation of the release of arachidonic acid to form PG that plays a critical role in pain mechanism
Summary
Medicinal plants are used to manage pain and inflammatory disorders in traditional medicine. We used both artificial intelligence (AI) based models inform of adaptive neuro-fuzzy inference system and artificial neural network (ANN) as well as a linear model, namely; stepwise linear regression in modelling the performance of four different inflammatory biomarkers namely; interleukin (1L)-1β, 1L-6, tumour necrosis factor (TNF)-α and prostaglandin E2 (PGE2). This modelling was done using number of abdominal writes, the reaction time of paw licking in mice and paw oedema diameter as the input variables.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
