Abstract
Purpose: The kidneys serve as the excretory organ of the body. The assessment of serum creatinine, urea, and electrolytes (Na+, K+, HCO3-, Cl-) are crucial and sensitive biochemical markers that are usually involved in the diagnosis of renal impairments (Agbasi et al. 2010; Tietz, 2008; Yakubu et al. 2003).
 Methodology: Thirty-six animals were grouped into 6, with 6 rats in each group. The animals were housed at room temperature in metal cages. Animals in each group had access to clean water and commercial standard rodent pellets. Group 1 (control group) received distilled water, Groups 2-6 were treated orally with low, middle, and high doses of ethanolic extract of Justicia secunda leaves daily for 42 days.
 Findings: A significant increase in the level of urea concentration was observed compared to the control. From the present study, Na+, K+, Cl-, and HCO3 increased significantly in the moderate and high dose groups.
 Unique contribution to theory, policy and practice: In conclusion, this study indicates that ethanolic extract of Justicia secunda increased the serum level of urea, creatinine, and electrolytes.
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