Abstract
Ethanol (1, 2 and 3 g/kg, intravenously) decreased the severity of the ischemic arrhythmias in rats with ligation of the left coronary artery and subsequent coronary reperfusion. Reperfusion arrhythmias occuring intensively after occlusion times of 5 and 15 min, respectively, were however not antagonized. Similar results were obtained in isolated perfused rat hearts with final concentrations of 4 and 6 mg ethanol/ml. In rats with reperfusion after 60 min of coronary occlusion, 2 g ethanol/kg significantly reduced the percentage of the ischemic area which underwent necrosis. Moreover, the increase in the wet weight/dry weight ratio of the lungs, as measure of edema formation, was prevented. The ethanol effects are discussed in the light of present knowledge of the pathogenesis of arrhythmias and myocardial necrosis in experimental myocardial infarction.
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