Abstract
The present study was investigate the hepatoprotective effect of ethanol extract Mymercodia pendans(EEMP) in white rats. Hepatotoxicity was induced in rats by oral administration of Paracetamol (PCM) 250 mg/kg/d for ten days. Effect of concurrent administration of EEMP at a dose of 250 mg/kg/d given by oral route was determined using aspartate transaminase (AST), alanine transaminase (ALT) and histological paramater as indicators of hepar damage. The results showed that ethanol extract of M. pendans resulted in significant (p<0.05) decrease in paracetamol-induced by increasing levels of liver enzymes. Histopathologic examination revealed that PCM administration produced liver cell necrosis, degeneration, hemorrhage and congestion, but the degree of induced hepatotoxicity-paracetamol was reduce by treatment with EEMP. This can be concluded that ethanolic extract of M. pendans possess hepatoprotective activity.
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