Abstract
2325 Previously, our group reported that estrogen replacement inhibited postnatal muscle fiber growth in the rat soleus, a slow muscle. PURPOSE: To examine the effects of estrogen replacement on the rat plantaris, a fast muscle, during a period of physiological growth. METHODS: Eight-week-old female Sprague-Dawley rats were assigned to 3 treatment groups (OVX, SHAM and OVX/E2). All groups underwent surgery but only OVX and OVX/E2 groups had the ovaries removed. The OVX/E2 group received 17-beta estradiol replacement whereas the OVX group received a corn oil vehicle. Rats were sacrificed 4 weeks after surgery and the plantaris muscle was removed. Measurements included muscle weight, fiber size and fiber type composition by myosin heavy chain (MHC) immunostaining. Comparisons among groups were made using a single factor ANOVA and Bonferroni's post-hoc analysis. RESULTS:TableCONCLUSIONS: Estrogen replacement reduces type I (slow) muscle fiber size in the fast plantaris muscle. Supported by University at Buffalo Gender Institute (G.B., K.M.) and the Kapoor foundation (G.B.)
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