Abstract
To show if a small dose of estrogen can interfere with the effect of Cimetidine on male reproductive system. Five groups of five randomly selected adult male rats were utilized. Rats were given food (laboratory rat chow) and water ad libitum. Rats were treated orally with Cimetidine 50mg/kg and subcutaneous injection with estradiol 0.01µg for 60 days. The animals were grouped as: group1, treated from days 1-10. Group2, treated from days 20-30. Group3, treated from days 40-50. Group4, treated from days 50-60. Group 5 received no treatment as a control group. Blood samples were taken from the eyes (by using capillary tubes) to measure testosterone (T) and follicular stimulating hormone (FSH) levels. Measurement of weights of the reproductive organs including the testis, epididymis (head, body, and tail), seminal vesicle and prostate were done. Body weight for each animal was recorded before and after treatment. Also we counted the total sperm count and the percentage of dead and alive spermatozoa for the treated groups using Eosin–negrosin stain. The testis weight and prostate weight was significantly increased in both groups 3 and 4, while seminal vesicle weight was significantly reduced. FSH levels were significantly increased, while testosterone levels were unchanged. Total sperm count and a number of a live sperms were significantly reduced and the number of dead sperms was significantly increased among the treated groups. Cimetidine has hazards on male reproductive function while estrogen didn't play any role to abolish this action.
Highlights
Cimetidine (Tagamet) is a H2 receptor antagonist. (Winters et al, 1979) has used initially in the treatment of gastric and duodenal ulcers
This study aims to answer two important questions: 1. Can exposure to estrogen interfere on male fertility when the male is receiving cimetidine?
The weight of testis in G1 and G2 was not statistically different from the control group while there was a significant increase in testis weight in G3 and G4 as compared with control group
Summary
Cimetidine (Tagamet) is a H2 receptor antagonist. (Winters et al, 1979) has used initially in the treatment of gastric and duodenal ulcers. (Winters et al, 1979) has used initially in the treatment of gastric and duodenal ulcers. Cimetidine (Tagamet) is a H2 receptor antagonist. It is currently sold "over the counter" to reduce gastric acid secretion and the resulting discomfort as heart burn. Cimetidine has been widely prescribed worldwide during the last 20 -30 years. A well known side effect of cimetidine is its ability to compete and block dihydrotestosterone (DHT) by occupying the androgen receptor (Winters et al, 1979), making it a weak antiandrogen for tissues requiring DHT. Ali Saeed Hammodi & Sajeda Al-Chalabi & Rana A.
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