Abstract
The effect of estradiol or estradiol and progesterone on weight water content and glycogen content of uterus cervix and vagina in ovariectomized guinea pigs was surveyed briefly. 4 groups of 5 guinea pigs ovariectomized for 1 year received: 1) 1 mcg estradiol benzoate at 1 and 24 hours .4 mg progesterone at 48 hours and were killed 2 hours after estrus detected by the lordosis response; 2) 1 mcg estradiol at 0 and 24 hours and oil at 48 hours; 3) 100 mcg estradiol at 0 and 24 hours and oil at 48 hours; 4) controls (treatment not specified). Uterine tissue weights increased significantly in all treated groups (p less than .01); vaginal tissue was not weighed; water content remained unchanged. Significant weight gain in cervix was measured after 122 mcg estradiol and the combined treatment. The only significant increase in glycogen was in cervix after 1 mcg estrogen. The uterus had about 5% mo re water content in all groups than did the other tissues. This lack of glycogen response differs from the definite glycogen deposition in rats and hamsters.
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More From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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