Abstract
AS HAS RECENTLY BEEN EMPHASIZED (1), the ageing organism presents a large variety of important and unsolved problems. That the terminal stages of life are commonly marked by gradually increasing decrepitude is a matter of common knowledge but the time, severity and speed of its development vary widely. Some men enjoy a fairly high degree of preservation of functions for as much as a century whereas others meet advancing decrepitude and ultimate death within three decades. An obvious need is to determine to what extent the decrepitude can be ameliorated or postponed. The fact that both longevity and senescent vigor are importantly determined by hereditary factors does not necessarily mean that they are not subject to considerable degrees of modification. A study, of which this report constitutes one item, has been undertaken in an attempt to modify the vigor of ageing rats, using spontaneous activity as a criterion.
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