Abstract
The aim of the study was to assess changes in the functional activity of 2D-positive natural killer cells (NKG2D) and interferon status in patients with recurrence of herpes virus infection under the influence of Esberitox.Materials and methods. We studied 30 patients aged 22-45 years old with frequent relapsing labial herpes, previously verified by PCR. The frequency ofexacerbations at the time of the study was 6 (5.3 ± 1.4) and more than once a year. Patients were initially examined within 24 hours of the appearance of rashes.The expression of CD314 on the surface of CD3-CD56 lymphocytes was determined by flow cytometry(EPICS XL, Beckman Coulter). The content of cytokines (α-and γ-IFN) in supernatants was determined by enzyme immunoassay (IBL, Germany). Patients took Esberitox tablets, 2 tablets x 3 times a day, and daily1-gram tablets of Valacyclovir for 7 days. The control group consisted of 10 patients receiving only tablet valacyclovir.Results. As a result of the study, it was found that the final leveling of symptoms with combined treatment with Esberitox was noted by the end of 5-6 days, with basic treatment - by 9-10 days. There was a decrease in the relapse rate (3 patients) during the observation period within 2 months after the end of the course of treatment.In patients receiving basic Valacyclovir therapy, relapses during the observation period were recorded in more than half of the examined individuals (6 patients). The positive dynamics of the increase in the level of γ-IFN and α-IFN in patients of the main group and itsalmost absence in the control group were established.The dynamics of surface expression of the NKG2D receptor on peripheral blood NK cells showed an increase parameters under the influence of the Esberitox drug compared with Valacyclovir monotherapy, with no significant changes in other lymphocyte subpopulations. Conclusions. The administration of Esberitox in case of frequently recurring herpes virus infection is a promising method of combined immuno-adaptive therapy, which requires further careful study.
Highlights
We studied 30 patients aged 22-45 years old with frequent relapsing labial herpes, previously verified by PCR
Chief of Laboratory Clinic of Immunology and Allergology “Forpost”
Summary
Влияние препарата Эсберитокс на функциональную активность 2D-позитивных натуральных киллерных клеток (NKG2D) и интерфероновый статус у больных с рецидивом инфекции вируса простого герпеса. Целью исследования было оценить изменения функциональной активности 2D-позитивных натуральных киллерных клеток (NKG2D) и интерферонового статуса у больных с рецидивом герпесвирусной инфекции под влиянием препарата Эсберитокс. Исследовано 30 пациентов в возрасте 22-45 лет с часто рецидивирующим лабиальным герпесом, верифицированным ранее методом ПЦР. Пациенты первично обследовались в пределах 24 часов от момента появления высыпаний. Экспрессию CD314 на поверхности CD3-CD56 лимфоцитов определяли методом проточной цитофлюориметрии (EРICS XL, Beckman Coulter). Содержание цитокинов (α-и γ-IFN) в супернатантах определяли иммуноферментным методом (IBL, Германия). Пациенты принимали таблетки Эсберитокс по 2 таб. Х 3 раза в день и таблетированный Валацикловир в суточной дозировке 1 грамм на протяжении 7 дней. Контрольную группу составили 10 пациентов, получающих только таблетированный Валацикловир
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