The effect of erythropoietin on rehabilitation of lumbar degenerative scoliosis surgery

Abstract

Objective To investigate the effect of erythropoietin (EPO) on rehabilitation of lumbar degenerative scoliosis patients. Methods Design a prospective study of a double-blind randomized distribution. All patients were randomly divided into two groups. Group A: EPO was injected every two days from 7 days ago, and 10 000 U per injection. The injection lasted for 2 weeks. Group B: Contrast group was not treate. The changes of the 2 groups in red blood cells (RBC), hemoglobin (Hb), hematocrit (Hct) before operation and 7 days after operation were recorded and analyzed.Measurement results are (3.6±0.7)×1012/L, (127.0±11.0) g/L, (41.1±3.9)% and (3.2±0.5)×1012/L, (116.2±8.8) g/L, (36.6±3.5)%. The volume of blood loss and blood transfusion and quantity of drainage fluid after operation in 24 h were recorded and analyzed too. Contrast the results of bone marrow puncture findings before operation. Results The degree of anemia in group A was less than B (P=0.008, 0.017). The amount of blood transfusion in group A was less than B (P=0.029). Mean blood transfusion volume in group A was less than B (P=0.011). Tn the system of erythrocyte, the quantity of early, middle and late erythroblast in group A was less than B (P=0.010, 0.216, 0.087). Conclusion The patients who use EPO before spine surgery have less risk and lighter degree of anemia and fewer complications and faster recovery. Key words: Human erythropoietin; Anemia; Recovery; Lateral curvature