Abstract
Objective. This experimental study exam-ined the effect of erythropoietin (Epo) in a rat model and particularly in a hypoxia-reoxygenation (HR) protocol. The effect of that molecule was studied biochemically using blood mean chloride (Cl) levels. Materials and methods. 40 rats of mean weight 247.7 g were used in the study. Cl levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reoxygenation. Erythropoietin was admin-istered only in groups C and D.Results. Epo administration non-signifi-cantly decreased Cl levels by 1.07%+0.91% (p=0.2635). Reoxygenation time non-significantly decreased Cl levels by 0.68%+0.92% (P= 0.4457). However, eryth-ropoietin administration and reoxygena-tion time together produced a non-signifi-cant combined effect in decreasing Cl levels by 0.74%+0.54% (P= 0.1701). Conclusions. Epo administration, reoxy-genation time and their interaction have non-significant, short-term, decreasing ef-fects on Cl levels.
Highlights
Erythropoietin (Epo) is generally one of the more well studied growth factors
The concept is the knowledge promotion away from the original action of Epo as a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia; which stimulates red blood cell production in the bone marrow
The aim of this experimental study was to examine the effect of Epo on a rat model and in an hypoxia and reoxygenation (HR) protocol
Summary
Erythropoietin (Epo) is generally one of the more well studied growth factors. Epo is implicated in over 29,194 known biomedical studies at present. At least 10.39% of these studies concern tissue hypoxia and reoxygenation (HR) experiments. The concept is the knowledge promotion away from the original action of Epo as a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia; which stimulates red blood cell production (erythropoiesis) in the bone marrow. A numeric evaluation of Epo efficacy was yielded by a meta-analysis of 34 published studies, based on the same experimental setting, using the same endpoints (table 1). The aim of this experimental study was to examine the effect of Epo on a rat model and in an HR protocol. The effects of that model were studied by measuring the blood mean chloride (Cl) levels
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