Abstract
The influence of epileptiform seizures evoked by intrahippocampal injection of kainic acid on morphological changes of hippocampus and related brain regions was analyzed in rabbits using catecholamine histofluorescence, monoamine oxidase, acetylcholinesterase and Nissl staining methods. It was found that kainic acid induced generalized electroencephalographic seizures and a disappearance of hippocampal neurons. These effects did not affect the volume of neurons in septum and locus coeruleus. In the injected hippocampus, kainic acid destroyed hippocampal pyramidal cells and induced some sprouting of catecholamine, acetylcholinesterase-positive and monoamine oxidase-positive nerve fibers near the injection site. These results indicate that intrahippocampal kainic acid injection does not provoke a retrograde, transsynaptic degeneration in the medial septum and locus coeruleus, the brain regions which innervate the hippocampus.
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