Abstract
Background and Objective: Malnutrition is a major complication of inflammatory bowel disease (IBD). Our aim of the study was to examine the effects of Modulen IBD supplementation, which was administered to IBD patients without limiting their daily diet in addition to medical treatment, on the clinical, laboratory, anthropometric values, and disease activities of these patients. Materials and Methods: Seventy three children with IBD were evaluated retrospectively. The cases were classified as those who had Crohn disease receiving (CD-M; n = 16) or not receiving Modulen IBD (CD; n = 19) and those who had ulcerative colitis receiving (UC-M; n = 13) or not receiving Modulen IBD (UC; n = 25). Disease activities, laboratory values, remission rates, and anthropometric measurements of the groups were compared. In addition to IBD treatment, Modulen IBD in which half of the daily calorie requirement was provided was given for eight weeks. Results: In the third month of treatment, 14 (88%) patients were in remission in CD-M group and eight (42%) patients were in remission in CD group. The height and weight z scores, which were low at the time of diagnosis, improved in the first week in CD-M group. Inflammatory parameters (UC) were significantly lower in the UC-M group compared to the UC group in first and third months. In the third month, eight (62%) patients in the UC-M group and four (16%) in the UC group were remitted clinically and in terms of laboratory values. Conclusions: TGF-β-rich enteral nutrition support in children with IBD is an easy, effective, and reliable approach. It was shown that TGF-β-rich enteral nutritional supplementation enabled the disease to enter the remission earlier, and contributed to the early recovery of weight and height scores.
Highlights
Growth retardation and malnutrition is a major complication seen in children with inflammatory bowel disease (IBD)
Two patients with Crohn’s disease (CD) were excluded from the study because they could not tolerate Modulen IBD orally, two patients were excluded because they had incomplete data in their files, and two patients were excluded because they had a history of surgery
Albumin levels were normalized in the Crohn disease who received Modulen IBD (CD-M) group and a statistically significant decrease was observed in erythrocyte sedimentation rate (ESR) compared to the CD group
Summary
Growth retardation and malnutrition is a major complication seen in children with inflammatory bowel disease (IBD). In the development of malnutrition in patients with IBD, various factors play a role such as malabsorption, increased intestinal loss, catabolic effects of systemic inflammation, and anorexia nervosa developed due to the chronic inflammation in bowel [3]. Nutritional support plays an important role in the prevention of complications such as malnutrition, osteoporosis, and micronutrient deficiency in the treatment. Malnutrition is a major complication of inflammatory bowel disease (IBD). Our aim of the study was to examine the effects of Modulen IBD supplementation, which was administered to IBD patients without limiting their daily diet in addition to medical treatment, on the clinical, laboratory, anthropometric values, and disease activities of these patients
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