Abstract
Oxidative stress can reduce the quality of sleep in patients with type 2 diabetes. Antioxidants such as polyphenols may increase sleep quality by improving oxidative stress conditions. Considering the antioxidant properties of Ellagic acid (EA), this study was designed to evaluate the effect of EA on sleep quality in diabetic patients. In this study, 44 diabetic patients were recruited. Patients who met the inclusion criteria that were randomly allocated consumed a capsule containing 180 mg of EA per day (n = 22) or placebo (n = 22) for 8 weeks. Anthropometric factors, physical activity, food intake, and Petersburg’s Sleep Quality (PSQI) questionnaire were assessed at the beginning and end of the study. Kolmogorov-Smirnov test, paired sample t test and independent sample t test were used to analyze the data. At the end of the study, the mean scores of PSQI and sleep subgroups in the intervention group were significantly lower than in the placebo group (p 0.05). According to these findings, intake of EA may help to improve the sleep quality in patients with type 2 diabetes. These effects may be due to the antioxidant effects of this polyphenol.
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