Abstract
Action potentials of various regions of hypertrophied and non-hypertrophied rat and cat hearts were recorded. It was found that the action potential duration is a function of the recording position within the heart: prolonged action potentials are characteristic for cells which are exposed to high chronic wall stress, both in hypertrophied and non-hypertrophied hearts. This is true for cells of sub-endo-cardial as compared to sub-epicardial wall layers, as well as cells of left ventricular as compared to right ventricular myocardium. The prolongation of the action potential is certainly responsible to some extent for the longer lasting mechanical activity of the corresponding heart muscle preparations measured in the isometric contraction mode.
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