Abstract
A frog nerve-muscle preparation was used to study the effects of depolarization and hyperpolarization of the transmission of single impulses at nerve endings. The efficacy of synaptic transmission was determined by the value of the end-plate potential led off intracellularly from the muscle fiber. Depolarization of the nerve endings produced a rapid reduction of up to 10–20% in the trans-synaptic action of the ending. Hyperpolarization of the endings caused the efficacy of trans-synaptic action to increase slowly for three minutes. In such cases the end-plate potential rose to 3 or 4 times the control level. These changes were observed only with a local polarization of the region of the nerve endings, and were absent when the preterminal branches of the nerve were polarized.
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