Abstract
In aqueous solutions, neutral lipid bilayers form multilamellar lipid vesicles in which the repeat spacing is highly sensitive to water soluble molecules and ions [1]. In this work, we report and compare electrical polarizabilities [2] of two classes of zwitterionic solutes: Good's buffers and amino acids. We find that both pH buffers and amino acids are more polarizable than common monovalent ions in proportion to molecular weight. In addition, there is a clear distinction between how the polarizability values for organic molecules scale with molecular weight compared to salt ions: molecular weight dependence is almost linear for organic molecules while the dependence for salt ions is a power law with exponent 2/3. These results are used to explain the interactions between lipid membranes in the presence of solutes.[1] Koerner et al., Biophys. J. 101, 2011, [2] Szymanski and Petrache, J. Chem. Phys. 143, 2011.
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