Abstract
Periapical bone reaction to Eikenella corrodens endotoxin was examined in seven adult mongrel dogs. Mandibular third and fourth premolars were biomechanically prepared and injected with E. corrodens 23834 endotoxin, Escherichia coli 055:B5 endotoxin, or pyrogen-free water at weekly intervals for 4 wk. Radiographs and blood samples were obtained weekly for 12 wk and one animal was killed for histological evaluation at the end of the test period. Radiographically, the most rapidly progressing and most extensive lessions in periapical bone were observed in those canals treated with E. corrodens endotoxin. No antibody titers were detected in sera from any of the dogs during the observation period. Histological examination showed significant bone destribution and heavy inflammatory cell infiltrate. These results provide further evidence that endotoxins of the Gram-negative oral microflora play a major role in intiating and perpetuating inflammation and bone destruction associated with endodontically disease tissues.
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