Abstract
The relation between the normal level of spontaneous activity in rats and the function of the sex glands has been demonstrated in several experiments. Wang (’23) found the running activity of adult females in revolving drums to be reduced as much as 95 per cent by removal of the ovaries. Hoskins (’25) found that removal of the testes in adult males had a similar depressive effect. In keeping with these observations made on adults, it was found further that rats spayed or castrated before puberty, from 28–40 days of age, showed a constant low level of activity throughout life which averaged less than 2,000 revolutions per day. (Wang, Richter and Guttmacher, ’25; Richter and Wislocki, ’28.) That the sluggishness of these gonadectomized animals was due to the absence of the sex glands was demonstrated by replacement therapy which consisted of the implantation of the sex glands or the injection of their extracts. Successful implantation of ovaries into rats castrated or spayed before puberty caused an increas...
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