Abstract
The impact of granule drying technique (oven and freeze) on tablet strength and dissolution characteristics was investigated for a range of propyl gallate (PG)/microcrystalline cellulose (MCC)/water granules generated via extrusion-spheronization. The tablet compaction data indicated that the granule yield point (GYP) was significantly lower for the freeze-dried granular material. As a consequence, for tablets compacted to the same final applied stress, the tablet surface was visibly smoother than that of the oven-dried counterparts. Granules with a lower GYP produced tablets of increased strength. Dissolution profiles were similar for both the oven- and freeze-dried samples with the exception of one formulation, where the freeze-dried material displayed a maximum dissolution rate nearly two-fold that of the oven-dried analogue. The degree of tablet break-up during dissolution dominated the mass transfer of PG.
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