Abstract
1. 1. The effect of various compounds on the isolated fore gut and hind gut of Locusta migratoria and hind gut of Periplaneta americana is described. 2. 2. The hind gut of locust was sensitive to 5-hydroxytryptamine, dopamine and tyramine but showed no response to acetylcholine, adrenaline, DOPA and tryptamine. 3. 3. The fore gut of locust contracted in the presence of 5-hydroxytryptamine, dopamine, adrenaline and noradrenaline. It did not respond to acetylcholine, tryptamine and DOPA. 4. 4. The response of locust intestine to 5-hydroxytryptamine was inhibited by bromolysergic acid diethylamide. 5. 5. The hind gut of Periplaneta was sensitive to tryptamine and 5-hydroxytryptamine. The response to 5-HT was inhibited by lysergic acid diethylamide. 6. 6. It is suggested that the intestine of locust would be of use in the analysis of possible chemical mediators in insects.
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