Abstract
Purpose: Since aflatoxins B1 can cause autism in mice by disrupting DNA repair and altering the stability of the genome, the study aims to see whether DNA pol alleviate autism tasted by AFB1, because of its DNA repair function. Whats more, the study would identify whether aflatoxins gene damage can be repaired by DNA polymerase . Methods: In this study, four groups of BTBR mice were selected. The positive group was normal BTBR mice, the other group was AFB1-infected mice, and the experimental group was AFB1-infected mice treated with DNA polymerase , the negative group was AFB1-infected mice which were treated with blank vector. RT-PCR was then used to detect changes in transcript levels as an indicator of whether DNA polymerase could be used to treat aflatoxins autism. Possible results: There are three main possible results: (1) DNA polymerase can cure autism completely. (2) DNA polymerase can cure autism partially. (3) DNA polymerase has no therapeutic effect on autism. Conclusion: The results will provide important insights into the treatment of autism with DNA polymerase . It will increase our understanding of DNA repair function to improve peoples understanding and improve human health. It also points a way to develop clinical treatments for people in autism with aflatoxins.
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