Abstract
ABSTRACT Administration of milk to normal individuals in 6 divided doses during the day produced greater 24-hr urinary calcium excretion than the same amount of milk given in a single daily dose. To further study the effect of divided calcium doses on calcium metabolism, we performed radiocalcium kinetics and metabolic balance studies in 3 normal subjects. We found an increase in the efficiency of calcium absorption on the divided-dose regimen. This increase in absorbed calcium produced homeostatic changes in bone resorption as well as in urinary calcium excretion. Although the effect on calcium absorption may be due to hormone-induced changes on the gastrointestinal tract, a more likely explanation is that calcium in divided doses is less likely to saturate gastrointestinal absorption mechanisms. Therefore, calcium can be absorbed at a greater efficiency on the divided-dose regimen.
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