Abstract
The GIRK (G protein-activated inwardly rectifying potassium channel) channel is a potential target in the treatment of atrial fibrillation. These channels are selectively expressed in the atrium and they are not present in the ventricle thus the electrical remodelling of atrial heart muscle might be achieved by their inhibition. Diterpene alkaloids isolated from Aconitum and Consolida species exert activity on Na+ and K+ channels and most of them are highly toxic. Depending on skeletal type and substitution pattern the binding affinity thereby the physiological activity may be diverse. Compounds with selective inhibitory activity on GIRK channels might be useful in the treatment of chronic atrial fibrillation. The aim of this work was the investigation of diterpene alkaloids on the GIRK channel.
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