Abstract
Abstract Background Diplotaenia turcica has been used traditionally to diabetes treatment. In this study, the effects of D. turcica root extract (DT) on diabetes mellitus induced by streptozotocin (STZ) were investigated. Materials and methods In this study, 78 male rats were used, rats were divided into 9 groups randomly. In diabetic groups, STZ was given a single dose of 45 mg/kg by intraperitoneally. DT (50, 100 and 200 mg/kg) and glibenclamide (5 mg/kg) were given by orally. Blood and pancreas tissue samples were taken for biochemical and pathological tests. Results It was found that glucose levels decreased, and insulin levels increased in the treatment groups compared with the diabetes group. In addition, only in 200 mg/kg DT dose group was found to decrease HbA1c levels. Pancreatic tissue analysis showed that MDA levels decreased and GSH levels and CAT, SOD, GSH-Px and GSH-R activities increased in diabetic rats treated with DT. Histopathological and immunohistochemical examinations of the pancreas showed significant improvements in the treatment with DT. Conclusion These results clearly show the antioxidant property of DT. The findings of this study showed that increased doses of DT may have a therapeutic effect on STZ-induced pancreatic damage.
Highlights
Diabetes mellitus (DM) is a metabolic disease that develops due to the irregularities in the carbohydrate, fat and protein metabolisms stemming from disorders of secretion or from the effect of insulin hormone, or both
At the end of the 28-day trial, the serum glucose level was measured as 166.86 ± 0.36 mg/dL in Group I and 654.60 ± 18.80 mg/dL in Group II, which consisted of STZ-induced diabetic rats
The serum insulin level of the STZinduced rats (Group II) was lower than the Group I (p < 0.05). This value was lower in the Groups IIIb, IVb, and Vb than the Group I, they was significantly higher than the Group II
Summary
Diabetes mellitus (DM) is a metabolic disease that develops due to the irregularities in the carbohydrate, fat and protein metabolisms stemming from disorders of secretion or from the effect of insulin hormone, or both. In diabetes and other metabolic diseases, it has been observed that the oxidative stress induced by the increase in free radical levels and the decrease in antioxidant defense level is effective [1]. Positive effects of many plants, which have antioxidant properties and are used in the traditional treatment of diabetes, have been supported in several scientific studies [3, 6]. Results: It was found that glucose levels decreased, and insulin levels increased in the treatment groups compared with the diabetes group. Pancreatic tissue analysis showed that MDA levels decreased and GSH levels and CAT, SOD, GSH-Px and GSH-R activities increased in diabetic rats treated with DT. The findings of this study showed that increased doses of DT may have a therapeutic effect on STZ-induced pancreatic damage
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