Abstract
The structure-dependent action of arylalkylhydrazines on brain and liver MAO using benzylamine, tyramine, dopamine, tryptamine and serotonin as substrates was studied. For all the substrates used the inhibitory power of unsubstituted arylalkylhydrazines with an alkyl chain ranging from —CH 2— to (—CH 2—) 5 decreased with increasing carbon chain length up to four methylene groups. The substance with five carbon alkyl chain exerted approximately the same action as the compound with three carbon alkyl chain. All analogues of these substances methylated on the carbon adjacent to the hydrazine group showed potent inhibitory properties. The deamination of dopamine, serotonin and tyramine was affected more strongly by the majority of MAO inhibitors, than that of benzylamine and tryptamine.
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