Abstract
The objective: development of the best vaccination regimen against pneumococcal infection in patients with chronic obstructive pulmonary disease (COPD) with consideration of changes in microbiological and clinical parameters.Subjects and Methods. 115 patients with COPD were randomized into 4 pneumococcal vaccination groups, they were examined and followed up for 4 years; 112 patients completed the study complying with the protocol. Detail medical history of all subjects was collected. To verify the diagnosis of COPD, all subjects underwent external respiratory function test and bronchodilator test (salbutamol, 400 μg) according to the standard method. The classic microbiological assessment was used in this study. The clinical effectiveness of vaccination was assessed. Statistical processing of the results was performed using StatPlus Pro 6.2.0.0 software (license number 2883).Results. Сonsecutive vaccination with pneumococcal conjugate and polysaccharide vaccines leads to decreased isolation rate of pneuniococcus from the sputum of CODP patients. The frequency of exacerbations, the need for antibiotic chemotherapy and hospitalizations also goes down.
Highlights
115 patients with COPD were randomized into 4 pneumococcal vaccination groups
112 patients completed the study complying with the protocol
The classic microbiological assessment was used in this study
Summary
Влияние разных схем вакцинации против пневмококковой инфекции на клиническое течение хронической обструктивной болезни легких: фокус на изменении микробиоценоза мокроты. Цель исследования: разработка оптимальной схемы вакцинации против пневмококковой инфекции у пациентов с хронической обструктивной болезнью легких (ХОБЛ) с учетом изменения микробиологических и клинических показателей. Проведены обследование и наблюдение в течение 4 лет за 115 пациентами с ХОБЛ, которые рандомизированы в 4 группы вакцинации против пневмококковой инфекции, 112 пациентов завершили исследование в соответствии с протоколом. С. Влияние разных схем вакцинации против пневмококковой инфекции на клиническое течение хронической обструктивной болезни легких: фокус на изменении микробиоценоза мокроты // Туберкулёз и болезни лёгких. The objective: development of the best vaccination regimen against pneumococcal infection in patients with chronic obstructive pulmonary disease (COPD) with consideration of changes in microbiological and clinical parameters
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