Abstract
A combination of sulphamethoxazol SMX and trimethoprim TMP is widly used in the treatment of various systemic infections . This investigation was carried out to see the effect of increasing concentration of surface active agents ( SAA ) used in suspensions on the absorption of both drugs from isolated rabbit ileum . The study was carried out at PH 7.4 and at 37°C . The SAA chosen were tween 80, sodium laurylsulphate ( SLS ), polyethylene glycole ( PEG400 ), and PEG4000 at a concentrations of 0.1%w/v , 1%w/v, 2%w/v and 15% w/v (Note : 15% was chosen for the purpose of the investigation not as a concentration for formulation ). It was found that the absorption of both drugs decreased as a function of increasing the concentration of the different SAA.
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