The effect of different concentrations of metformin drug on the concentration of glucose and lipid profile in the male rats induced diabetes by alloxan.

Abstract

The present study aimed to find out the effect of Metformin drug on some of biochemical parameters, including Glucose and lipid profile: Cholesterol, Triglycerides, High density lipoprotein HDL-CH, and low density lipoprotein LDL-C Male albino rats were used in this study.
 The results showed that the development of diabetes induced by alloxan led to a significant increase in the levels of glucose, cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) compared with the control group. Treatment of animals in the third and fourth groups with metformin at two different concentrations of (500,850) mg led to a significant decrease in glucose and cholesterol levels, compared with the aloxan group, the results were similar to the control group, and the treatment resulted in a significant decrease in triglycerides and low-density lipoproteins (LDL-C) compared with the alloxan group and gave results comparable to the control group (healthy controls).