The effect of dietary protein on the pathophysiology of acute ovine haemonchosis

Abstract

An experiment was conducted to examine the effect of dietary protein on the pathophysiology iof acute haemonchosis in Finn Dorset/Dorset horn lambs. Erythrokinetic and metabolic studies using 51Cr-red cells, 59Fe-trasferrin and 125I-albumine and digestive efficiency and nitrogen balance measurements wer conducted between 19 and 39 days after infection. Identical radioisotopic and nutritional studies were conducted later on pair-fed control lambs. The results demonstrated that lambs on a law protein diet (88 g crude protein (CP) kg −1 dry matter (DM)) were less able to withstand the pathyphysiological consequences of infection with 350 Haemonchus contortus larvae kg −1 body weight than lambs given a high protein (170 g CP kg −1 DM) diet, despite similar worm budens. Erythrokinetic studies indicated that abomasal blood loss was similar in both groups of infected lambs, and circulating red cell volumes were reduced and plasma volumes were expanded to a similar degree in both groups. The majority of infected lambs in both dietary groups responded equally well to the gastric haemorrhage by increasing the rate of red cell production and their absorption of dietary iron was greater than in the control lambs. Albumin catabolism was increased in both groups of infected lambs, particularly in those given the low protein diet. Within each dietary group there were no differences in the digestibilities of the various proximate fractions of the experimental diets and no differences in the urinary of faecal nitrogen losses between infected lambs and their pair-fed control. However, loss of appetive was a major feature of the disease, particularly in the lambs given the low protein diet and this feature appeared to be crucial in determining the ability of the infected sheep to withstand the pathophysiological effects of the parasite.