Abstract
Since phenobarbital is known to induce drug-metabolizing enzymes and to alter the effectiveness of certain carcinogens, its influence on 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin carcinogenesis has been examined. Skin tumor development was studied in groups of hairless mice treated with repeated applications of DMBA and maintained on either a control diet or one supplemented with 0.05% phenobarbital. The feeding of phenobarbital concurrently with the application of DMBA delayed the appearance of papillomas initially, but the suppression of the ultimate tumor yield was variable, and appeared to be dependent on the dose of the carcinogen and the age-dependent toxicity response of the mice. Phenobarbital was ineffective when DMBA was applied in sufficiently large amounts to elicit marked cutaneous damage, or when dietary phenobarbital was started 1 week after the cessation of the DMBA treatment. Although the dietary administration of phenobarbital caused an apparent decrease in the final incidence of papillomas and sarcomas, the feeding did not appear to modify the macroscopic skin response or change the incidence of carcinomas.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.