Abstract
The effect of dietary composition on cholesterol formation in the liver of alloxan diabetic rats was studied. Cholesterol formation in these animals was maintained at a subnormal level when the diet had a high content of simple sugar (sucrose, glucose or fructose) without fat, but was severely impaired with diets of all other compositions tested. The possible mechanism of maintenance of hepatic cholesterol synthesis in diabetic rats on a diet with a high content of simple sugar without fat is discussed. The rate of cholesterol synthesis in the liver was not always proportional to the plasma cholesterol level.
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