THE EFFECT OF DICLAZURIL AND MADURAMICIN ALONE OR TOGETHER IN CONTROLLING CECAL COCCIDIOSIS IN CHICKENS

Abstract

Coccidiosis in chicken farms are considered as one of the most serious problems affecting both small and large poultry producers. Eimeria tenella now is consider as one of the most pathogenic and important Eimeria species affecting about 90% of intensive broiler production. This study was carried out to evaluate the efficacy of maduramicin (5ppm), diclazuril (2.5ppm) and both drugs together on healthy and experimentally infected chicken with E.tenella (50000 sporulated oocyst) on 15th day of age after the symptoms of infection had appeared on 5th day of infection for 3 successive days from 20th day to 22nd day and from 30th day to 32nd day of age. The results revealed that the infected group treated with both of maduramicin and diclazuril did not show any antagonistic interaction between them but leading to the best results among all infected treated groups by overcome clinical signs, decrease mortality rate, lesion scoring, give the lowest count of oocyst shedding and represented the best improvement in biochemical parameters throughout the experiment. This reflects the synergistic interaction between them without any significant adverse effect. The efficacy of diclazuril was superior to maduramicin in treatment of cecal coccidiosis by marked improvement on cecal integrity and reduction of the oocyst shedding. Non infected treated groups did not show any significant difference than negative control group during the experimental period and this reflects the safe use of both drugs either individually or together