The effect of di- and trivalent iron on the intestinal absorption of aluminum in rats

Abstract

The effect of iron (Fe) on the intestinal absorption of aluminum (Al) was studied in an in situ perfusion system of rat small intestine in combination with systemic and portal blood sampling. The gut was perfused with media containing 0.0, 10.0, 15.0, 20.0, and 25.0 mmol/liter Al chloride and 5 mmol/liter Fe(II) or Fe(III) chloride at pH 3.0. Neither luminal disappearance nor intestinal absorption of Al were affected by Fe(III). Fe(II), however, enhanced luminal disappearance and reduced absorption of Al.