Abstract
Dextran 70 was infused into four healthy volunteers and one patient with mild von Willebrand's disease. Ex vivo thrombi formed in Chandler tubes exhibited clear structural changes after the infusion. The large platelet aggregates of the thrombus head had ceased to form. The changes were most pronounced 2–4 hours after the infusion. The thrombi from the von Willebrand patient had a different structure before infusion, indicating the importance of factor VIII for the cohesion of the platelet aggregates. The change in structure of the thrombi after the infusion coincided with an impairment of the function of factor VIII in the healthy volunteers as well as in the patient. On infusion i.v. of factor VIII concentrate to the von Willebrand patient the platelets regained their potential to aggregate and formed a thrombus head. The morphological changes may explain the increased lysability of thrombi after infusion of dextran.
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